Embryo transfer media compounds boost IVF success rates

Current research suggests that specific compounds, called adherence compounds, when added into embryo transfer culture media boost IVF success rates.

Embryo transfer media compounds

Hyaluronic acid (HA), an adherence compound, can boost IVF success rates

Assisted reproductive technologies are generally considered to be successful medical procedures, but not successful enough. Couples diagnosed with infertility are commonly given an IVF (in vitro fertilisation) or ICSI (intracytoplasmisc injection) treatment. These treatments are the most successful forms of infertility treatments in IVF clinics and have similar success rates, however not successful enough given the increased demand for test-tube babies.

A great body of research is focused on studying how to boost IVF success rates while minimizing any adverse effects like multiple pregnancies. Part of this research has studied the effects of the addition of adherence compounds into the embryo transfer culture media.

Currently a scientific review analyzing 16 randomized studies on the above objective has reported that hyaluronic acid (HA), an adherence compound, can boost IVF success rates. Researchers compared embryo transfer media with different concentrations of the hyaluronic acid including high, low and no HA. As for the outcome most studies conducted their research by measuring live birth rates, pregnancy chances, implantation rates and multiple pregnancy rates. The women that took part in the studies aged 27.5-35.7 in average.

According to the review results hyaluronic acid increased IVF success rates in terms of live birth and pregnancy chances when added in the culture medium used for embryo transfer (450 vs 367). Fertility experts think that adherent compounds may actually increase the embryo potential for adhering to the uterus.

On the other hand, it was also found that the addition of the adherent compound increased chances of multiple pregnancies. Researchers argue that this result is probably linked to the number of embryos transferred by fertility doctors which quite often exceeds the 2 embryos. Thus, in such cases where more than one embryo is transferred into the womb, an adherent compound by promoting successful implantation could increase risk of a multiple pregnancy. Complementary studies investigating the outcome of using these enhanced transfer media for only single embryo transfer are necessary for optimizing these compounds’ contribution to a successful IVF outcome.

Would you risk a multiple pregnancy if it was to boost your pregnancy chances? We would be happy to receive your feedback.

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Ask for some music to boost your success rates

Have you thought about asking for some music to boost your IVF success? According to a recent study, you should!

music boost fertility

Music may actually improve success rates of In Vitro Fertilisation.

A study carried out at Marques Institute fertility clinic in Barcelona reported that music may actually improve success rates of in vitro fertilisation. In fact researchers of the Marques Institute reported an approximately 5% increase of fertilisation rates for eggs incubated under the sound of different types of music genres.

Researchers collected and analyzed approximately 1,000 eggs from 114 different patients attended the fertility clinic. Those eggs were injected with sperm and then split into two groups. The first group of eggs was incubated into an incubator connected with an iPod and a loud speaker system playing all kinds of music; from pop (Michael Jackson and Madonna to classical works by Bach Mozart and Vivaldi and even heavier metal sounds from Nirvana and Metallica. The second group of eggs was kept into conventional incubators without any music application.

Once the incubation period was completed they assessed fertilisation success rates for both group. They found that success rates were higher by 4.8% in the incubators in which music had been played.

Fertility experts explain that no matter how weird this outcome may sound it is based on scientific facts. The key factor here is the vibrations produced by music sound, as embryos cannot hear music until they grow up to 14 weeks.  Researchers believe that these vibrations may actually help the fertilized eggs remove their toxic waste products. It is also possible that vibrations could ease the nutrients passage into the egg.

According to the study researchers, music can be a way of mimicking the natural environment of the embryo. The embryo has to go a long way from the fallopian tubes all the way up to the womb keeping it in motion, experiencing a dynamic environment with vibrations that could possibly ease its waste products’ discard.

Previous research has shown that dynamic incubation could possibly promote successful embryo development so music might just be an easy way of achieving such a dynamic embryo culture.  The first IVF baby to be created in the presence of music was born in the UK just a few years ago.

So, if music can give your eggs good vibes what tunes would you want on their IVF playlist?

Hey! If you found this post interesting or useful, you can help us get even better by subscribing to our newsletter. Just write your email and you’ll have the latest news regarding fertility issues. Thank you once more for your help.